Possible evidence for free precession of a strongly magnetized neutron star in the magnetar 4U 0142+61.

Magnetars are a special type of neutron stars, considered to have extreme dipole magnetic fields reaching ∼ 10(11) T. The magnetar 4 U 0142+61, one of the prototypes of this class, was studied in broadband x rays (0.5-70 keV) with the Suzaku observatory. In hard x rays (15-40 keV), its 8.69 sec pulsations suffered slow phase modulations by ± 0.7 sec, with a period of ∼ 15 h. When this effect is interpreted as free precession of the neutron star, the object is inferred to deviate from spherical symmetry by ∼ 1.6 × 10(-4) in its moments of inertia. This deformation, when ascribed to magnetic pressure, suggests a strong toroidal magnetic field, ∼ 10(12) T, residing inside the object. This provides one of the first observational approaches towards toroidal magnetic fields of magnetars.

Malignant histiocytosis-like B-cell lymphoma, a distinct pathologic variant of intravascular lymphomatosis: a report of five cases and review of the literature.

Malignant histiocytosis (MH)-like B-cell lymphoma (BCL) is a neoplastic proliferation of large B cells clinically characterized by fever, hepatosplenomegaly, haemophagocytosis and abnormal laboratory data, without lymphadenopathy or skin lesions. Interestingly, most cases have been reported in Asian patients, and it is unclear whether MH-like BCL is biologically distinct from conventional large B-cell lymphomas. We report five Japanese patients with MH-like BCL. Biopsied specimens of bone marrow, liver and/or spleen showed infiltration of neoplastic B cells accompanied by haemophagocytosing histiocytes. Lymphoma cells were positive for CD19, CD20 and HLA-DR surface antigens, and negative for CD5 and CD10. In four cases elevated serum levels of interleukin (IL)-6 and the soluble IL-2 receptor isoform were noted, but not IL-1beta, IL-2 or tumour necrosis factor-alpha. Autopsies of two cases were pathologically diagnosed as intravascular lymphomatosis (IVL). Based on these observations, the current and nine previous cases reported as MH-like BCL in Japan were re-evaluated. They appear to form a peculiar variant of IVL, characterized by bone marrow involvement at presentation, haemophagocytic syndrome, and a rapidly aggressive clinical course, but rarely neurological complications or skin lesions. This variant may merit separate consideration because of the problems posed in the initial diagnosis and therapeutic approaches.

Finite element analysis for stresses in the craniofacial sutures produced by maxillary protraction forces applied at the upper canines.

The purpose of this study was to investigate the nature of stress distributions in the craniofacial sutures produced by orthopaedic maxillary protraction forces applied to the upper canines. A three-dimensional finite element model of the craniofacial complex was developed for finite element analysis. An anteriorly directed force of 1.0 kg was applied to the upper canines in three different directions, i.e. parallel, 30 degrees upwards and downwards to the functional occlusal plane. Normal stresses acting on the sutural systems were greatest when force was applied in the 30 degrees upward direction. Furthermore, relatively large compressive stresses were induced in the frontonasal and frontomaxillary sutures, indicating that forward and upward rotation of the nasomaxillary complex was produced with substantial distortion of the complex, by the forces applied in both parallel and 30 degrees upward directions. A 30 degrees downward force produced almost uniform tensile stresses in the zygomaticotemporal and zygomaticomaxillary sutures, with least compressive stresses in the frontonasal and frontomaxillary sutures located in the superior region of the complex. This would indicate a uniform stretch of the nasomaxillary complex in both anterior and inferior directions, with negligible distortion of the complex and would be appropriate for accelerating natural growth of the nasomaxillary complex.

[Studies on respiratory infections in primary care clinic (III). Distribution of bacteria isolated from patients with respiratory infections visiting 21 private clinics in the Tohoku District of Japan].

The bacteriology of the isolates from the throat swab and the sputum respectively of 2,539 patients with respiratory infections visiting 21 private clinics in Tohoku district of Japan during the period from January to April in 1989 was documented. Of the 2,539 patients, 1,694 had an acute upper respiratory infection, 609 had acute bronchitis, 46 had acute pneumonia, 84 had acute exacerbation of chronic respiratory infections and 106 had respiratory infections without diagnosis registered. 1887 (74.3%) strains of potential pathogens were recovered from 1507 (59.4%) of the 2539 cases. The rate of recovery of potential pathogens was very high in patients of the younger age. These patients had elevated body-temperature. There were statistically significant differences in recovery rate when classified by diagnosis, prefecture and the period of investigation. Of the 1,887 strains, 996 (52.8%) were gram-positive and 891 (47.2%) were gram-negative bacteria. The rate of recovery of gram-negative bacteria was high in patients who were less than 10 years old and more than 51 years old, in patients with pneumonia and chronic respiratory infections, and in patients with fever. Of the 1,887 strains, those which exceeded 100 were Staphylococcus aureus (481 strains), Haemophilus influenzae (340 strains), Streptococcus pneumoniae (329 strains), Streptococcus pyogenes (117 strains) and Acinetobacter spp. (100 strains). Species other than those mentioned above had less than 100 strains. In this group there were 39 strains of Branhamella catarrhalis, 32 strains of Escherichia coli, 97 strains of Klebsiella spp., 40 strains of Enterobacter spp., 25 strains of Serratia spp., 12 strains of Pseudomonas aeruginosa and 43 strains of Pseudomonas putida. There was a remarkable difference in recovery rate of each species when classified by diagnosis, age class, prefecture and the period of investigation, respectively. The above results indicated that gram-positive bacteria are more frequent than gram-negative bacteria, that enterobacteriaceae and glucose-non-fermentative gram-negative bacteria are only rarely found in primary care clinics, and that the bacteriology in primary care clinic is different from that of medical school-affiliated hospitals.

[Studies on respiratory infections in primary care clinic (IV). Antibiotic sensitivity of bacteria isolated from patients with respiratory infections visiting 21 private clinics in the Tohoku District of Japan].

We determined the MICs of ampicillin, methicillin, cefaclor, cefixime, cefteram, ofloxacin and ciprofloxacin against a total of 1,448 strains from 11 species: 464 strains of Staphylococcus aureus, 306 strains of Streptococcus pneumoniae, 114 strains of Streptococcus pyogenes, 37 strains of Branhamella catarrhalis, 329 strains of Haemophilus influenzae, 32 strains of Escherichia coli, 66 strains of Klebsiella pneumoniae, 26 strains of Enterobacter cloacae, 20 strains of Serratia marcescens, 12 strains of Pseudomonas aeruginosa and 42 strains of Acinetobacter calcoaceticus, isolated from the throat swab and the sputum of 2,539 patients with respiratory infections who visited 21 private clinics in Tohoku district of Japan during the period from January to April in 1989. Ciprofloxacin and ofloxacin were more active against S. aureus, B. catarrhalis, P. aeruginosa and A. calcoaceticus than other antibiotics. Ampicillin and cefteram were more active against S. pneumoniae and S. pyogenes than other antibiotics. New-quinolones and cephems of new-generation were active against H. influenzae, E. coli, K. pneumoniae, E. cloacae and S. marcescens. Of 30 strains of S. aureus which were resistant (MIC greater than or equal to 12.5 micrograms/ml) to ampicillin, only one strain was resistant (MIC greater than or equal to 12.5 micrograms/ml) to methicillin. Twenty strains (6.5%) of S. pneumoniae and 49 strains (14.9%) of H. influenzae were resistant (MIC greater than or equal to 1.56 micrograms/ml) to ampicillin. Of 101 strains of H. influenzae of which their beta-lactamase activity was determined by Nitrocephin-method, 27 (26.7%) were beta-lactamase-positive strains. The above results indicated that MRSA is only rarely found in primary care clinics but the incidence of ampicillin-resistant H. influenzae in primary care clinics is almost the same as that of the intensive care clinic, i.e. medical school-affiliated hospitals. Therefore caution should be exercised as regards antibiotic resistance of the causative organism even in primary care clinics.

Effects of directions of maxillary protraction forces on biomechanical changes in craniofacial complex.

The purpose of this study was to investigate the effect of directions of extraoral maxillary protraction forces on biomechanical changes in the craniofacial complex, using the three-dimensional finite element method (FEM). A three-dimensional FEM model was developed on the basis of a young, human dry skull. The model consisted of 2918 nodes and 1776 solid elements. An anteriorly directed 1.0 Kg force was applied to the buccal surface of the maxillary first molar in directions varying from -90 to 90 degrees to the occlusal plane. The displacement pattern of the entire craniofacial complex was evaluated. Further, the stress distributions were determined in three transverse planes associated with parallel, and 30 degrees upward and downward forces. As the force direction was more upward, repositioning of the craniofacial complex became larger in both the horizontal and vertical directions. Displacements were most translatory in loading with the forces applied in the directions ranging from -45 to -30 degrees to the occlusal plane. High stress levels were observed in the nasomaxillary complex and its surrounding structures. However, the patterns of stress distribution within the complex were different for three loading conditions. A downward protraction force produced the most uniform stress distribution. It is shown that the force direction plays an important role in determining the repositioning and the stress distributions in the craniofacial complex.

Biomechanical effect of anteriorly directed extraoral forces on the craniofacial complex: a study using the finite element method.

This study was designed to investigate the biomechanical effect of protractive maxillary orthopedic forces on the craniofacial complex by use of the three-dimensional finite element method (FEM). The three-dimensional FEM model was developed on the basis of a dry skull of a young human being. The model consisted of 2918 nodes and 1776 solid elements. Eighteen cranial and facial sutural systems were integrated in the model. An anteriorly directed 1.0-kg force was applied on the buccal surfaces of the maxillary first molars in both a horizontal parallel direction and a 30 degree obliquely downward direction to the functional occlusal plane. The nasomaxillary complex showed a forward displacement with upward and forward rotation in a horizontal protraction case, whereas a downward force produced almost translatory repositioning of the complex in an anterior direction. High stress levels were observed in the nasomaxillary complex and its surrounding structures. However, the pattern of stress distributions within the complex was different in two force systems. A downward protraction force produced relatively uniform stress distributions, indicating the importance of the force direction in determining the stress distributions from various orthopedic forces.